Share this article Share with email Share with twitter Share with linkedin Share with facebook. liver. The main symptoms of acute chloroform poisoning depend upon the concentration of chloroform absorbed, rather than the route of exposure [6]. Original and Selected Communications from The New England Journal of Medicine — Chloroform in a Case of Poisoning by Strychnine DELAYED CHLOROFORM POISONING H. J. STANDER, M.D.. NEW YORK Ccev. Methyl chloroform (1, 1, 1-trichloroethane) is a widely used solvent in the United States. Context: Poisoning due to chloroform ingestion is rare. Foy G. British Medical Journal, 27 Jun 1891, 1(1591): 1406-1406 PMCID: PMC2273275. NAME 1.1 Substance Trichloromethane 1.2 Group Organochlorine solvent 1.3 Synonyms chloroform (Dutch, German, Polish), chloroform (IUPAC), chloroforme (French), chloroformium anaestheticum, chloroformum, chloroformum pro narcosi, cloroformio, formyl trichloride, methane … Deaths generally occurred in 2.4 h, but some were delayed as long as 2 wk after treatment. Gross pathologic examination showed liver and kidney changes at doses as low as 250 mg/kg. The toxicity is believed to be similar in both inhalation and ingestion routes of exposure, with mortality predominantly resulting from anoxia secondary to central nervous system depression. Keywords: chloroform, poisoning, N-acetylcysteine INTRODUCTION Chloroform (trichloromethane, CHCl3), is a colorless, volatile liquid with a pleasant ethereal odor. N.Y. (From. CDCl 3 is a common solvent used in NMR spectroscopy.Deuterochloroform is produced by the haloform reaction, [citation needed] the reaction of acetone (or ethanol) with sodium hypochlorite or calcium hypochlorite. Most cases of Chloroform is a ubiquitous atmospheric and water contaminant in negligible amount.1 Chloroform was first discovered in 1831 and was used for general anesthesia. Free to read . Treatment of Chloroform-Poisoning. The haloform process is now obsolete for the production of ordinary chloroform. The patient recovered from the acute episode only to develop delayed chloroform poisoning two days later, reaching a crisis on the fifth day, from which he ultimately recovered. Symptoms of chloroform poisoning are those of stupor, from which the patient cannot be roused. Excessive absorption of this substance through the lungs or gastrointestinal tract produces central nervous system (CNS) depression proportional to the amount absorbed. CHLOROFORM International Programme on Chemical Safety Poisons Information Monograph 121 Chemical 1. No abstract provided. A case is described of acute chloroform poisoning, following imbibition of four fluid ounces of liquid chloroform. The classic features of acute chloroform toxicity include central nervous system (CNS) and respiratory depression, and delayed hepatotoxicity. Abstract . This may be preceded by signs of great irritation of the stomach; as chloroform is very pungent and heating when swallowed. When chloroform was given by gavage to male rats, an LD 50 of 2,000 mg/kg (confidence range, 1,050–3,800 mg/kg) was determined (Torkelson et al., 1976). Deuterated chloroform is an isotopologue of chloroform with a single deuterium atom. The average serum chloroform level in fatal cases of inhalational chloroform poisoning was 64 μg/mL, significantly lower than our patient.
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